This special supplement, sponsored by NIMHD, with an introductory editorial led by NIMHD Director Eliseo J. Pérez-Stable, M.D., with NIMHD Health Scientist Administrator Beda Jean-Francois, Ph.D., and NIMHD Chief of Staff Courtney Ferrell Aklin, Ph.D., reports on the use of health information technologies to reduce disparities in health care access and outcomes.